Wang Y., Zhao A., Morcillo R.J.L., Yu G., Xue H., Rufian, J.S., Sang Y., and Macho A.P. A bacterial effector uncovers a novel pathway involved in tolerance to bacterial wilt disease. Molecular Plant (2021) 30:S1674-2052(21)00159-3.

Rufian J.S., Rueda-Blanco J., Lopez-Marquez D., Macho A.P., Beuzon C.R., and Ruiz-Albert J. The bacterial effector HopZ1a acetylates MKK7 to suppress plant defense responses in Arabidopsis. New Phytologist (2021)

Ruiz-Lopez N., Pérez-Sancho J., Esteban Del Valle A., Haslam R.P., Vanneste S., Catalá R., Perea-Resa C., Van Damme D., García-Hernández S., Albert A, Vallarino J., Lin J., Friml J., Macho A.P., Salinas J., Rosado A., Napier J.A., Amorim-Silva V., and Botella M.A. Synaptotagmins at the endoplasmic reticulum-plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress. Plant Cell (2021) 4:koab122.

Li Z., Luo X., Ou Y., Jiao H., Peng L., Fu X., Macho A.P., Liu R., and He Y. JASMONATE-ZIM DOMAIN proteins engage Ploycomb chromatin modifiers to negatively modulate Jasmonate signalling in Arabidopsis. Molecular Plant (2021) 14(5):732-747.

de Pedro-Jove R., Sebastia P., Puigvert M., Macho A.P., Monteiro J.S., Coll N.S., Setubal J.C., and Valls M. Ralstonia solanacearum gene expression profiling at different potato infection stages. BMC Genomics (2021) 22(1):170.

Yu G., Xian L., Zhuang H., and Macho A.P. SGT1 is not required for bacterial PAMP-triggered immunity. Molecular Plant Pathology (2021) 22(1):145-150.

Ho Plagaro T., Morcillo R., Tamayo-Navarrete M.I., Huertas-Ruz R., Molinero-Rosales N., Lopez-Raez J.A., Haidour A., Macho A.P., and Garcia-Garrido J.M. DWARF14‐LIKE2 regulates arbuscule hyphal branching during arbuscular mycorrhizal symbiosis. New Phytologist (2021) 229(1):548-562.


Yu G., Xian L., Xue H., Yu W., Rufian J., Sang Y., Morcillo R., Wang Y., and Macho A.P. A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity. PLoS Pathogens (2020) 16(9): e1008933.

Xian L.#, Yu G.#, Wei Y., Rufian J.S., Li Y., Zhuang H., Xue H., Morcillo R.J.L., and Macho A.P. A bacterial effector protein hijacks plant metabolism to support pathogen nutrition. Cell Host & Microbe (2020), 28:548-557.e7.

Wei Y., Balaceanu A., Rufian J.S., Segonzac C., Zhao A., Morcillo R., and Macho A.P. An immune receptor complex evolved in soybean to perceive a polymorphic bacterial flagellin. Nature Communications (2020) 11:3763

Hao X, Lozano-Duran R.*, and Macho A.P.* Insights Into the Root Invasion by the Plant Pathogenic Bacterium Ralstonia solanacearum. Plants (2020) 9, 516.

Wang X., Ren M., Liu D., Zhang D., Zhang C., Lang Z., Macho A.P.*, Zhang M.,* and Zhu J.K.* Large-scale eQTL identification in Arabidopsis reveals novel candidate regulators of immune responses and other processes. Journal of Integrative Plant Biology (2020), online early (* Co-corresponding authors)

Lee E., Santana B.V.N., Samuels E., Benitez-Fuente F., Corsi E., Botella M.A., Perez-Sancho J., Vanneste S., Friml J., Macho A.P., Alves-Azevedo A., and Rosado A. Rare Earth Elements induce cytoskeleton-dependent and PI4P-associated rearrangement of SYT1/SYT5 ER-PM contact site complexes. Journal of Experimental Botany (2020) 71:3986–3998,

Morcillo R., Zhao A., Tamayo-Navarrete M.I., García-Garrido J.M., and Macho A.P. A versatile method for tomato root transformation followed by inoculation with Ralstonia solanacearum allows straightforward genetic analysis for the study of bacterial wilt disease. Journal of Visualized Experiments (2020) 157, e60302. Link. Click here to watch the video article.

Sang Y., Yu W., Zhuang H., Wei Y., Derevnina L., Yu G., Luo J., and Macho A.P. Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana. Plant Communications (2020) online early

Wang P., Hsu C-C., Du Y., Zhu P., Zhao C., Fu X., Zhang C., Paez J.S., Macho A.P., Tao W.A., and Zhu J-K. Mapping Proteome-Wide Targets of Protein Kinases in Plant Stress Responses. PNAS (2020) 117:3270-3280.

Morcillo RJL., Singh SK., He D., An G., Vilchez JI., Tang K., Yuan F., Sun Y., Shao C., Zhang S., Yang Y., Liu X., Dang Y., Wang W., Gao J., Huang W., Lei M., Song C-P., Zhu J-K., Macho AP., Pare PW., and Zhang H. Diacetyl determines plant-bacteria relation via phosphate-dependent modulation of plant immunity. EMBO Journal (2020) 39:e102602. Link


Garnelo-Gomez B., Zhang D., Rosas-Diaz T., Wei Y., Macho A.P., and Lozano-Duran R. The C4 protein from Tomato yellow leaf curl virus can broadly interact with plant receptor-like kinases. Viruses (2019) 31;11. Link

Rubio L., Diaz-Garcia J., Amorim-Silva V., Macho A.P., Botella M. A., and Fernandez J.A. ZosmaNRT2 encodes the putative sodium dependent high-affinity nitrate transporter of Zostera marina L. International Journal of Molecular Sciences (2019) Link

Sabbagh C. R. R., Carrère S., Lonjon F., Vailleau F., Macho A.P., Genin S., and Peeters N. Pangenomic type III effector database of the plant pathogenic Ralstonia spp. PeerJ (2019) 7:e7346 Link

Duan J., Lee K. P., Dogra V., Zhang S., Liu K., Caceres-Moreno C., Lv S., Xing W., Kato Y., Sakamoto W., Liu R., Macho A. P. and Kim C. Impaired PSII proteostasis promotes retrograde signaling via salicylic acid. Plant Physiology (2019) doi: 10.1104/pp.19.00483. Link


Amorim-Silva V., García-Moreno A., Castillo A.G., Lakhssassi N., Esteban del Valle A., Pérez-Sancho J., Li Y., Posé D., Pérez-Rodriguez J., Lin J., Valpuesta V., Borsani O., Zipfel C., Macho A.P., Botella M.A. TTL proteins scaffold brassinosteroid signaling components at the plasma membrane to optimize signal transduction in Arabidopsis. The Plant Cell (2019) doi: 10.1105/tpc.19.00150. Link


Macho A.P.* & Lozano-Duran R.* Molecular dialogues between viruses and receptor-like kinases in plants. Molecular Plant Pathology (2019) doi: 10.1111/mpp.12812. (* Co-corresponding authors). Link

Lee E., Vanneste S., Pérez-Sancho J., Benitez-Fuente F., Strelau M., Macho A.P., Botella M.A., Friml J. and Rosado A. Ionic stress enhances ER-PM connectivity via phosphoinositide-associated SYT1 contact site expansion in Arabidopsis. PNAS (2019). Link

Zheng X., Li X., Wang B., Cheng D., Li Y., Li W., Huang M., Tan X., Zhao G., Song B., Macho A.P., Chen H., and Xie C. A systematic screen of conserved R. solanacearum effectors reveals the role of RipAB, a nuclear-localized effector that suppresses immune responses in potato. Molecular Plant Pathology (2019) online early 2018, doi: 10.1111/mpp.12774. Link

Yu G., Xian L., Sang Y. and Macho A.P. Cautionary notes on the use of Agrobacterium-mediated transient expression upon SGT1 silencing in Nicotiana benthamiana. New Phytologist (2019) online early 2018, doi: 10.1111/nph.15601. Link

Wang Y., Li Y., Rosas-Diaz T., Caceres-Moreno C., Lozano-Duran R., and Macho A.P. The IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING 9 protein is a regulator of basal immunity in Arabidopsis thaliana. Molecular Plant-Microbe Interactions (2019) Online early 2018. Link



Rufián J.S., Lucia A., Rueda-Blanco J., Zumaquero A., Guevara C.M., Ortiz-Martin I., Ruiz-Aldea G., Macho A.P., Beuzon C.R. and Ruiz-Albert J. Suppression of HopZ effector-triggered plant immunity in a natural pathosystem. Frontiers in Plant Sciences (2018). Link


Zhao Y., Zhang Z., Gao J., Wang P., Hu T., Wang Z., Hou Y.J., Wan Y., Liu W., Xie S., Lu T., Xue L., Liu Y, Macho A.P., Tao W.A., Bressan R.A., and Zhu J.K. Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA-Independent SnRK2 Activity. Cell Reports (2018) 23: 3340 - 3351.e5. Link

Wei Y., Caceres-Moreno C., Jimenez-Gongora T., Wang K., Sang Y., Lozano-Duran R. and Macho A.P. The Ralstonia solanacearum csp22 peptide, but not flagellin-derived peptides, is perceived by plants from the Solanaceae family. Plant Biotechnology Journal (2018), ,16:1349-1362. Link



Wei Y. #, Sang Y. # and Macho A.P. The Ralstonia solanacearum type III effector RipAY is phosphorylated in plant cells to modulate its enzymatic activity. Frontiers in Plant Science (2017) Nov 7; 8: 1899. Link


Jiang G., Wei Z., Xu J., Chen H., Zhang Y., She X., Macho A.P., Ding W. and Liao B. Bacterial Wilt in China: history, current status and future perspectives. Frontiers in Plant Science (2017) Sep 11; 8: 1549. Link


Sun Y.#, Wang K.#, Caceres-Moreno C.#, Jia W., Chen A., Zhang H., Liu R.* and Macho A.P.* Genome sequencing and analysis of Ralstonia solanacearum phylotype I strains FJAT-91, FJAT-452 and FJAT-462 isolated from tomato, eggplant, and chilli pepper in China. Standards in Genomic Sciences (2017) 12:29. Link


Puigvert M., Guarischi-Sosa R., Zuluaga P., Coll N.S., Macho A.P., Setubal J.C. and Valls M. Transcriptomes of Ralstonia solanacearum during root colonization of Solanum commersonii. Frontiers in Plant Science (2017) 8: 370. Link

Sang Y.Y. & Macho A.P. Analysis of PAMP-triggered ROS Burst in Plant Immunity. Methods in Molecular Biology (2017) 1578:143-153. Link


Sang Y.Y., Wang Y.R., Ni H., Cazalé-Noel A.C., She Y.M., Peeters N. and Macho A.P. The Ralstonia solanacearum type-III effector RipAY targets plant redox regulators to suppress immune responses. Molecular Plant Pathology (2016). Final publication 2018 Jan; 19 (1): 129-142. Link

Rosas-Díaz T., Macho A.P., Beuzón C.R., Lozano-Durán R. and Bejarano E.R. The C2 Protein from the Geminivirus Tomato Yellow Leaf Curl Sardinia Virus Decreases Sensitivity to Jasmonates and Suppresses Jasmonate-Mediated Defences. Plants (2016) 5 (1), 8. Link


Macho A.P. Subversion of plant cellular functions by bacterial type-III effectors: beyond suppression of immunity. New Phytologist (2016) 210: 51-57. doi:10.1111/nph.13605 . Link